Prana Shakti

Chronic Pain/ Neuropathic Pain:

The most common indication for cannabis-based medicine (CBM) use is still to relieve chronic pain. The clinical evidence has found that there is a substantial evidence that CBM was effective for chronic pain treatment. Considering the current evidence, a panel of experts have recommended the use of CBM for neuropathic and nociplastic pain mechanisms too. They also suggested that CBM could be considered if there was a substantial inflammatory component and that CBD-only medicine could be tried initially due to its better safety profile.

Chronic Stress:

Stress causes considerable morbidity and economic loss that could be prevented by a safe, rapid and effective treatment. The stress response involves secretion of cortisol and catecholamines from the hypothalamus-pituitary-adrenal axis and sympathetic nervous system, and prolonged activity is a substantial causal contributor to many diseases, including nociplastic pain conditions and mental health disorders. Cannabinoid (CBD) enhances endocannabinoid signalling that arrests the stress response. Clinically, CBD has proven to be a safe and effective treatment for chronic stress

Anxiety Disorders/ Depression:

Anxiety disorders generally involve an excessive anticipation of future threats that is accompanied by excessive fear and are the most prevalent psychiatric disorders. Preclinical studies support the efficacy of low dose of CBD for anxiety. A study on placebo controlled found that a single dose of CBD significantly decreased symptoms of performance discomfort, anxiety and cognitive impairment. An open-label clinical trial found that CBD significantly decreased depressive symptoms. Pre-clinical models have demonstrated CBD to have anti-depressant effects that results from increased CB1 and 5-HT1A  signalling

Chronic Insomnia (Lack of Sleep or Inadequate Sleep):

Chronic Insomnia is one of the most prevalent complaints in primary care. Early work on whole plant cannabis showed that cannabis may help to improve sleep onset latency and sleep maintenance insomnia. An early-double blind randomized controlled trials found CBD in participants suffering from insomnia improved their duration of sleep significantly

The recommended dosing of CBM (cannabis-based medicine) is to start at a low dose twice a day (or once daily for insomnia) and gradually titrate the dose over two to three weeks until the participant’s optimal dose is discovered. So, it is desirable “to start low and go slow”. It is prudent to allow personalisation of optimal dose for effect and tolerability because the dose is dependent from person to person.

Dose may need to be adjusted as required for changes in indication severity, or changes in other medicines, foods or hepatic and renal function, heart related ailments that may affect CBM metabolism.

The spectrum of Vijaya leaf extract medicines has a good safety and tolerability profile, besides being effective in various disease conditions. High quality efficacy evidence is best for THC/CBD and other excipients in the spectrum. The best mode of administration is an oral option that provides effective sub-lingual absorption.

J. Clin. Med. 2022,11,5036
Bennet, M.I; et al A systemic review, Pain 2012, 153,359-365
THC and CBD medicines for chronic pain and mental health conditions, 2022

• • Boehnke et al. 2019; Ergisi et al. 2022
  • National Academic of Sciences, Engineering, and Medicine. 2017
  • Bhaskar et al. 2021
  • Henson et al. 2021
  • Eller-Smith et al. 2018, Henson et al. 2021, Sluka and Clauw 2016
  • Appiah-Kusi et al. 2020
  • American Psychiatric Association 2013
  • Bonaccorso et al. 2019
  • Morin and Benca. 2012
  • Babson et al. 2017

• Avoid taking if you are allergic or have an allergic reaction while consuming
• It is not recommended for breast-feeding women or during pregnancy
• For any patient having an underlying heart ailment, please consult your doctor.
• Please consult your doctor for any pre or post related surgeries.
• It is advisable to take this medicine only after a meal
• Avoid consuming this medicine under the influence of alcohol
• Keep the medication away from children
• Do not operate any machine/driving while on this medication

Consult your doctor for drug related interactions, use with sedatives or barbiturates, medicines that control the blood sugar levels.

The most effective mode of administration is when taken sub-lingual (under the tongue), counting the drops according to your recommended dose, as prescribed by your doctor. Hold the drops under your tongue for a minimum of 60 seconds. This allows the medicine to get absorbed effectively under your tongue, ensuring its therapeutic effects.

Remember to shake the bottle before every use

The medicine to be placed in a cool and dark place, away from direct sunlight

Consult your doctor for dose and duration.

Shake the bottle well before use